Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020.
Identifieur interne : 000245 ( Main/Exploration ); précédent : 000244; suivant : 000246Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020.
Auteurs : Anu Haveri [Finlande] ; Teemu Smura [Finlande] ; Suvi Kuivanen [Finlande] ; Pamela Österlund [Finlande] ; Jussi Hepojoki [Suisse] ; Niina Ikonen [Finlande] ; Marjaana Pitk Paasi [Finlande] ; Soile Blomqvist [Finlande] ; Esa Rönkkö [Finlande] ; Anu Kantele [Finlande] ; Tomas Strandin [Finlande] ; Hannimari Kallio-Kokko [Finlande] ; Laura Mannonen [Finlande] ; Maija Lappalainen [Finlande] ; Markku Broas [Finlande] ; Miao Jiang [Finlande] ; Lotta Siira [Finlande] ; Mika Salminen [Finlande] ; Taneli Puumalainen [Finlande] ; Jussi Sane [Finlande] ; Merit Melin [Finlande] ; Olli Vapalahti [Finlande] ; Carita Savolainen-Kopra [Finlande]Source :
- Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [ 1560-7917 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte, Anticorps antiviraux (sang), Chine, Coronavirus (génétique), Coronavirus (immunologie), Coronavirus (isolement et purification), Femelle, Finlande, Humains, Immunoglobuline A (sang), Immunoglobuline G (sang), Immunoglobuline M (sang), Infections asymptomatiques, Infections à coronavirus (diagnostic), Infections à coronavirus (transmission), Infections à coronavirus (virologie), Pandémies, Pneumopathie virale (diagnostic), Pneumopathie virale (transmission), Pneumopathie virale (virologie), Protéines de l'enveloppe virale, Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (étiologie), Technique d'immunofluorescence, Techniques de laboratoire clinique, Tests de neutralisation, Traçage des contacts, Virus du SRAS (immunologie), Virus du SRAS (pathogénicité), Voyage.
- MESH :
- diagnostic : Infections à coronavirus, Pneumopathie virale.
- génétique : Coronavirus.
- immunologie : Coronavirus, Syndrome respiratoire aigu sévère, Virus du SRAS.
- isolement et purification : Coronavirus.
- pathogénicité : Virus du SRAS.
- sang : Anticorps antiviraux, Immunoglobuline A, Immunoglobuline G, Immunoglobuline M.
- virologie : Infections à coronavirus, Pneumopathie virale, Syndrome respiratoire aigu sévère.
- étiologie : Infections à coronavirus, Pneumopathie virale, Syndrome respiratoire aigu sévère.
- Adulte, Chine, Femelle, Finlande, Humains, Infections asymptomatiques, Pandémies, Protéines de l'enveloppe virale, Technique d'immunofluorescence, Techniques de laboratoire clinique, Tests de neutralisation, Traçage des contacts, Voyage.
- Wicri :
- geographic : République populaire de Chine, Finlande.
English descriptors
- KwdEn :
- Adult, Antibodies, Viral (blood), Asymptomatic Infections, Betacoronavirus, China, Clinical Laboratory Techniques, Contact Tracing, Coronavirus (genetics), Coronavirus (immunology), Coronavirus (isolation & purification), Coronavirus Infections (diagnosis), Coronavirus Infections (transmission), Coronavirus Infections (virology), Female, Finland, Fluorescent Antibody Technique, Humans, Immunoglobulin A (blood), Immunoglobulin G (blood), Immunoglobulin M (blood), Neutralization Tests, Pandemics, Pneumonia, Viral (diagnosis), Pneumonia, Viral (transmission), Pneumonia, Viral (virology), SARS Virus (immunology), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (etiology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), Travel, Viral Envelope Proteins.
- MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M.
- geographic : China, Finland, Viral Envelope Proteins.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- etiology : Severe Acute Respiratory Syndrome.
- genetics : Coronavirus.
- immunology : Coronavirus, SARS Virus, Severe Acute Respiratory Syndrome.
- isolation & purification : Coronavirus.
- pathogenicity : SARS Virus.
- transmission : Coronavirus Infections, Pneumonia, Viral.
- virology : Coronavirus Infections, Pneumonia, Viral, Severe Acute Respiratory Syndrome.
- Adult, Asymptomatic Infections, Betacoronavirus, Clinical Laboratory Techniques, Contact Tracing, Female, Fluorescent Antibody Technique, Humans, Neutralization Tests, Pandemics, Travel.
Abstract
The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3-23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a single nucleotide substitution to the reference strain from Wuhan. Neutralising antibody response appeared within 9 days along with specific IgM and IgG response, targeting particularly nucleocapsid and spike proteins.
DOI: 10.2807/1560-7917.ES.2020.25.11.2000266
PubMed: 32209163
Affiliations:
- Finlande, Suisse
- Canton de Zurich, Uusimaa
- Helsinki, Zurich
- Université d'Helsinki, Université de Zurich
Links toward previous steps (curation, corpus...)
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Le document en format XML
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Pamela" uniqKey="Osterlund P" first="Pamela" last="Österlund">Pamela Österlund</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Hepojoki, Jussi" sort="Hepojoki, Jussi" uniqKey="Hepojoki J" first="Jussi" last="Hepojoki">Jussi Hepojoki</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zürich, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName><orgName type="university">Université de Zurich</orgName></affiliation></author><author><name sortKey="Ikonen, Niina" sort="Ikonen, Niina" uniqKey="Ikonen N" first="Niina" last="Ikonen">Niina Ikonen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Pitk Paasi, Marjaana" sort="Pitk Paasi, Marjaana" uniqKey="Pitk Paasi M" first="Marjaana" last="Pitk Paasi">Marjaana Pitk Paasi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Blomqvist, Soile" sort="Blomqvist, Soile" uniqKey="Blomqvist S" first="Soile" last="Blomqvist">Soile Blomqvist</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Ronkko, Esa" sort="Ronkko, Esa" uniqKey="Ronkko E" first="Esa" last="Rönkkö">Esa Rönkkö</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Kantele, Anu" sort="Kantele, Anu" uniqKey="Kantele A" first="Anu" last="Kantele">Anu Kantele</name><affiliation wicri:level="1"><nlm:affiliation>Inflammation Center, Infectious Diseases, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Inflammation Center, Infectious Diseases, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Strandin, Tomas" sort="Strandin, Tomas" uniqKey="Strandin T" first="Tomas" last="Strandin">Tomas Strandin</name><affiliation wicri:level="4"><nlm:affiliation>University of Helsinki, Medicum, Department of Virology, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki, Medicum, Department of Virology, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Kallio Kokko, Hannimari" sort="Kallio Kokko, Hannimari" uniqKey="Kallio Kokko H" first="Hannimari" last="Kallio-Kokko">Hannimari Kallio-Kokko</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Mannonen, Laura" sort="Mannonen, Laura" uniqKey="Mannonen L" first="Laura" last="Mannonen">Laura Mannonen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Lappalainen, Maija" sort="Lappalainen, Maija" uniqKey="Lappalainen M" first="Maija" last="Lappalainen">Maija Lappalainen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Broas, Markku" sort="Broas, Markku" uniqKey="Broas M" first="Markku" last="Broas">Markku Broas</name><affiliation wicri:level="1"><nlm:affiliation>Infection-Hospital Hygiene Unit, Lapland Central Hospital, Rovaniemi, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Infection-Hospital Hygiene Unit, Lapland Central Hospital, Rovaniemi</wicri:regionArea><wicri:noRegion>Rovaniemi</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Miao" sort="Jiang, Miao" uniqKey="Jiang M" first="Miao" last="Jiang">Miao Jiang</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Siira, Lotta" sort="Siira, Lotta" uniqKey="Siira L" first="Lotta" last="Siira">Lotta Siira</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Salminen, Mika" sort="Salminen, Mika" uniqKey="Salminen M" first="Mika" last="Salminen">Mika Salminen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Puumalainen, Taneli" sort="Puumalainen, Taneli" uniqKey="Puumalainen T" first="Taneli" last="Puumalainen">Taneli Puumalainen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Sane, Jussi" sort="Sane, Jussi" uniqKey="Sane J" first="Jussi" last="Sane">Jussi Sane</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Melin, Merit" sort="Melin, Merit" uniqKey="Melin M" first="Merit" last="Melin">Merit Melin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Vapalahti, Olli" sort="Vapalahti, Olli" uniqKey="Vapalahti O" first="Olli" last="Vapalahti">Olli Vapalahti</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Savolainen Kopra, Carita" sort="Savolainen Kopra, Carita" uniqKey="Savolainen Kopra C" first="Carita" last="Savolainen-Kopra">Carita Savolainen-Kopra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, 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wicri:level="4"><nlm:affiliation>University of Helsinki, Medicum, Department of Virology, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki, Medicum, Department of Virology, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Kuivanen, Suvi" sort="Kuivanen, Suvi" uniqKey="Kuivanen S" first="Suvi" last="Kuivanen">Suvi Kuivanen</name><affiliation wicri:level="4"><nlm:affiliation>University of Helsinki, Medicum, Department of Virology, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki, Medicum, Department of Virology, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Osterlund, Pamela" sort="Osterlund, Pamela" uniqKey="Osterlund P" first="Pamela" last="Österlund">Pamela Österlund</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Hepojoki, Jussi" sort="Hepojoki, Jussi" uniqKey="Hepojoki J" first="Jussi" last="Hepojoki">Jussi Hepojoki</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zürich, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName><orgName type="university">Université de Zurich</orgName></affiliation></author><author><name sortKey="Ikonen, Niina" sort="Ikonen, Niina" uniqKey="Ikonen N" first="Niina" last="Ikonen">Niina Ikonen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Pitk Paasi, Marjaana" sort="Pitk Paasi, Marjaana" uniqKey="Pitk Paasi M" first="Marjaana" last="Pitk Paasi">Marjaana Pitk Paasi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Blomqvist, Soile" sort="Blomqvist, Soile" uniqKey="Blomqvist S" first="Soile" last="Blomqvist">Soile Blomqvist</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Ronkko, Esa" sort="Ronkko, Esa" uniqKey="Ronkko E" first="Esa" last="Rönkkö">Esa Rönkkö</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Kantele, Anu" sort="Kantele, Anu" uniqKey="Kantele A" first="Anu" last="Kantele">Anu Kantele</name><affiliation wicri:level="1"><nlm:affiliation>Inflammation Center, Infectious Diseases, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Inflammation Center, Infectious Diseases, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Strandin, Tomas" sort="Strandin, Tomas" uniqKey="Strandin T" first="Tomas" last="Strandin">Tomas Strandin</name><affiliation wicri:level="4"><nlm:affiliation>University of Helsinki, Medicum, Department of Virology, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki, Medicum, Department of Virology, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Kallio Kokko, Hannimari" sort="Kallio Kokko, Hannimari" uniqKey="Kallio Kokko H" first="Hannimari" last="Kallio-Kokko">Hannimari Kallio-Kokko</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Mannonen, Laura" sort="Mannonen, Laura" uniqKey="Mannonen L" first="Laura" last="Mannonen">Laura Mannonen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Lappalainen, Maija" sort="Lappalainen, Maija" uniqKey="Lappalainen M" first="Maija" last="Lappalainen">Maija Lappalainen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Broas, Markku" sort="Broas, Markku" uniqKey="Broas M" first="Markku" last="Broas">Markku Broas</name><affiliation wicri:level="1"><nlm:affiliation>Infection-Hospital Hygiene Unit, Lapland Central Hospital, Rovaniemi, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Infection-Hospital Hygiene Unit, Lapland Central Hospital, Rovaniemi</wicri:regionArea><wicri:noRegion>Rovaniemi</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Miao" sort="Jiang, Miao" uniqKey="Jiang M" first="Miao" last="Jiang">Miao Jiang</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Siira, Lotta" sort="Siira, Lotta" uniqKey="Siira L" first="Lotta" last="Siira">Lotta Siira</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Salminen, Mika" sort="Salminen, Mika" uniqKey="Salminen M" first="Mika" last="Salminen">Mika Salminen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Puumalainen, Taneli" sort="Puumalainen, Taneli" uniqKey="Puumalainen T" first="Taneli" last="Puumalainen">Taneli Puumalainen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Sane, Jussi" sort="Sane, Jussi" uniqKey="Sane J" first="Jussi" last="Sane">Jussi Sane</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Melin, Merit" sort="Melin, Merit" uniqKey="Melin M" first="Merit" last="Melin">Merit Melin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Vapalahti, Olli" sort="Vapalahti, Olli" uniqKey="Vapalahti O" first="Olli" last="Vapalahti">Olli Vapalahti</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Savolainen Kopra, Carita" sort="Savolainen Kopra, Carita" uniqKey="Savolainen Kopra C" first="Carita" last="Savolainen-Kopra">Carita Savolainen-Kopra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author></analytic><series><title level="j">Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin</title><idno type="eISSN">1560-7917</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antibodies, Viral (blood)</term><term>Asymptomatic Infections</term><term>Betacoronavirus</term><term>China</term><term>Clinical Laboratory Techniques</term><term>Contact Tracing</term><term>Coronavirus (genetics)</term><term>Coronavirus (immunology)</term><term>Coronavirus (isolation & purification)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (transmission)</term><term>Coronavirus Infections (virology)</term><term>Female</term><term>Finland</term><term>Fluorescent Antibody Technique</term><term>Humans</term><term>Immunoglobulin A (blood)</term><term>Immunoglobulin G (blood)</term><term>Immunoglobulin M (blood)</term><term>Neutralization Tests</term><term>Pandemics</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (transmission)</term><term>Pneumonia, Viral (virology)</term><term>SARS Virus (immunology)</term><term>SARS Virus (pathogenicity)</term><term>Severe Acute Respiratory Syndrome (etiology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Travel</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Anticorps antiviraux (sang)</term><term>Chine</term><term>Coronavirus (génétique)</term><term>Coronavirus (immunologie)</term><term>Coronavirus (isolement et purification)</term><term>Femelle</term><term>Finlande</term><term>Humains</term><term>Immunoglobuline A (sang)</term><term>Immunoglobuline G (sang)</term><term>Immunoglobuline M (sang)</term><term>Infections asymptomatiques</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (transmission)</term><term>Infections à coronavirus (virologie)</term><term>Pandémies</term><term>Pneumopathie virale (diagnostic)</term><term>Pneumopathie virale (transmission)</term><term>Pneumopathie virale (virologie)</term><term>Protéines de l'enveloppe virale</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Syndrome respiratoire aigu sévère (étiologie)</term><term>Technique d'immunofluorescence</term><term>Techniques de laboratoire clinique</term><term>Tests de neutralisation</term><term>Traçage des contacts</term><term>Virus du SRAS (immunologie)</term><term>Virus du SRAS (pathogénicité)</term><term>Voyage</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin A</term><term>Immunoglobulin G</term><term>Immunoglobulin M</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term><term>Finland</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Immunoglobuline A</term><term>Immunoglobuline G</term><term>Immunoglobuline M</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Asymptomatic Infections</term><term>Betacoronavirus</term><term>Clinical Laboratory Techniques</term><term>Contact Tracing</term><term>Female</term><term>Fluorescent Antibody Technique</term><term>Humans</term><term>Neutralization Tests</term><term>Pandemics</term><term>Travel</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Chine</term><term>Femelle</term><term>Finlande</term><term>Humains</term><term>Infections asymptomatiques</term><term>Pandémies</term><term>Protéines de l'enveloppe virale</term><term>Technique d'immunofluorescence</term><term>Techniques de laboratoire clinique</term><term>Tests de neutralisation</term><term>Traçage des contacts</term><term>Voyage</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term><term>Finlande</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3-23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a single nucleotide substitution to the reference strain from Wuhan. Neutralising antibody response appeared within 9 days along with specific IgM and IgG response, targeting particularly nucleocapsid and spike proteins.</div></front></TEI><affiliations><list><country><li>Finlande</li><li>Suisse</li></country><region><li>Canton de Zurich</li><li>Uusimaa</li></region><settlement><li>Helsinki</li><li>Zurich</li></settlement><orgName><li>Université d'Helsinki</li><li>Université de Zurich</li></orgName></list><tree><country name="Finlande"><noRegion><name sortKey="Haveri, Anu" sort="Haveri, Anu" uniqKey="Haveri A" first="Anu" last="Haveri">Anu Haveri</name></noRegion><name sortKey="Blomqvist, Soile" sort="Blomqvist, Soile" uniqKey="Blomqvist S" first="Soile" last="Blomqvist">Soile Blomqvist</name><name sortKey="Broas, Markku" sort="Broas, Markku" uniqKey="Broas M" first="Markku" last="Broas">Markku Broas</name><name sortKey="Ikonen, Niina" sort="Ikonen, Niina" uniqKey="Ikonen N" first="Niina" last="Ikonen">Niina Ikonen</name><name sortKey="Jiang, Miao" sort="Jiang, Miao" uniqKey="Jiang M" first="Miao" last="Jiang">Miao Jiang</name><name sortKey="Kallio Kokko, Hannimari" sort="Kallio Kokko, Hannimari" uniqKey="Kallio Kokko H" first="Hannimari" last="Kallio-Kokko">Hannimari Kallio-Kokko</name><name sortKey="Kantele, Anu" sort="Kantele, Anu" uniqKey="Kantele A" first="Anu" last="Kantele">Anu Kantele</name><name sortKey="Kuivanen, Suvi" sort="Kuivanen, Suvi" uniqKey="Kuivanen S" first="Suvi" last="Kuivanen">Suvi Kuivanen</name><name sortKey="Lappalainen, Maija" sort="Lappalainen, Maija" uniqKey="Lappalainen M" first="Maija" last="Lappalainen">Maija Lappalainen</name><name sortKey="Mannonen, Laura" sort="Mannonen, Laura" uniqKey="Mannonen L" first="Laura" last="Mannonen">Laura Mannonen</name><name sortKey="Melin, Merit" sort="Melin, Merit" uniqKey="Melin M" first="Merit" last="Melin">Merit Melin</name><name sortKey="Osterlund, Pamela" sort="Osterlund, Pamela" uniqKey="Osterlund P" first="Pamela" last="Österlund">Pamela Österlund</name><name sortKey="Pitk Paasi, Marjaana" sort="Pitk Paasi, Marjaana" uniqKey="Pitk Paasi M" first="Marjaana" last="Pitk Paasi">Marjaana Pitk Paasi</name><name sortKey="Puumalainen, Taneli" sort="Puumalainen, Taneli" uniqKey="Puumalainen T" first="Taneli" last="Puumalainen">Taneli Puumalainen</name><name sortKey="Ronkko, Esa" sort="Ronkko, Esa" uniqKey="Ronkko E" first="Esa" last="Rönkkö">Esa Rönkkö</name><name sortKey="Salminen, Mika" sort="Salminen, Mika" uniqKey="Salminen M" first="Mika" last="Salminen">Mika Salminen</name><name sortKey="Sane, Jussi" sort="Sane, Jussi" uniqKey="Sane J" first="Jussi" last="Sane">Jussi Sane</name><name sortKey="Savolainen Kopra, Carita" sort="Savolainen Kopra, Carita" uniqKey="Savolainen Kopra C" first="Carita" last="Savolainen-Kopra">Carita Savolainen-Kopra</name><name sortKey="Siira, Lotta" sort="Siira, Lotta" uniqKey="Siira L" first="Lotta" last="Siira">Lotta Siira</name><name sortKey="Smura, Teemu" sort="Smura, Teemu" uniqKey="Smura T" first="Teemu" last="Smura">Teemu Smura</name><name sortKey="Strandin, Tomas" sort="Strandin, Tomas" uniqKey="Strandin T" first="Tomas" last="Strandin">Tomas Strandin</name><name sortKey="Vapalahti, Olli" sort="Vapalahti, Olli" uniqKey="Vapalahti O" first="Olli" last="Vapalahti">Olli Vapalahti</name></country><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Hepojoki, Jussi" sort="Hepojoki, Jussi" uniqKey="Hepojoki J" first="Jussi" last="Hepojoki">Jussi Hepojoki</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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